The US Justice Department is seeking nearly US$100 million in damages from Armstrong, charging that he cheated the government when the US Postal Service sponsored the team he led.
The decision by Judge Christopher Cooper, in Washington, DC, comes as a major blow to Armstrong, who had requested the case be thrown out. He claims the lawsuits were unfounded and that the US Postal Service benefited from his lucrative sponsorship deal.
Cooper overruled that argument in his 37-page decision, arguing that a jury must decide the issue of injury suffered by the United States postal services.
The US Postal Service paid more than US$32 million to Tailwind Sports Corporation, the now-defunct Lance Armstrong cycling team.
Armstrong in October 2012 was stripped of his seven victories (1999-2005) in the Tour de France after the American Anti-Doping Agency (USADA) accused him of actively taking part in one of the most sophisticated doping programs ever seen in sports.
Armstrong in January 2013 finally acknowledged to American television host Oprah Winfrey that he took part in doping.